Regional Headquarters
With a diverse and experienced talent pool to draw from, the Business and Professional Services sector has become a major economic cluster in the region, particularly in finance, insurance and healthcare. Numerous universities and colleges including the University of Tennessee, an advanced communications infrastructure and world-class technical expertise continue to make this region and excellent location for this sector.
| Company | Location | Product | Additional locations |
| Advanced Labelworx, Inc. | Anderson | Manufacturer of pressure-sensitive labels | Operations in SC |
| A.J. Metler Hauling & Rigging | Knox | Trucking company | Other terminal locations in TN and TX |
| Altar'd State | Knox | Women’s clothing & fashion boutiques | over 50 locations in the southeast |
| American Accessories Inc. | Knox | Importer of premium items; | Operations in FL and GA |
| American Apartment Management Co. | Knox | Apartment management | Operations in GA, IL, MS, NC, OH, SC, VA, WV, and WI |
| American Holiday Van Lines Inc. | Knox | Moving and storage | Operations throughout TN |
| Appalachian Underwriters | Anderson | Insurance firm | Offices in TN, CA, FL, GA, MO & SC |
| Aqua-Chem, Inc. | Knox | Manufacturing water desalinization equipment | |
| ARC Automotive, Inc. | Knox | Manufacturing air bag inflators | Operations in MI; China, Germany, Japan, Korea & Mexico |
| Axle Logistics, LLC | Knox | Third-party logistics broker including truckload, LTL, intermodal, and warehousing with customers throughout North America | |
| Bandit Lites | Knox | Theatrical producers and service providers | Operations nationally and internationally |
| Brunswick Boat Group | Knox | Pleasure boat manufacturer | Operations in 9 states & 9 nations |
| Bush Brothers and Co. | Knox | Processed foods packers and distributors | Operations in TN, AR, LA, MI, OK, and WI |
| Cellular Sales, Inc. | Knox | Largest exclusive authorized dealer of Verizon Wireless services | National |
| Clayton Homes, Inc. | Blount | Specializes in manufactured housing | National |
| Coastal Supply Co. | Knox | HVAC equipment | Operations throughout East TN |
| Connor Concepts, Inc. | Knox | Restaurant operations | Restaurant operations including: Chop House; Connor’s Steaks |
| Copper Cellar Corp. | Knox | Restaurant operations | Restaurant operations including: Calhoun’s/Cherokee Grill/ Chesapeake’s/Copper Cellar/Smoky Mountain Brewery |
| CTI, Inc. | Knox | Supplier of products and services for the positron emission tomography (PET) market | Operationsin Berkley, CA and worldwide |
| Cumberland Clarklift, Inc. | Knox | Manufacturer of industrial machinery and equipment | Operations in TN |
| DenTek Oral Care, Inc. | Blount | Dental care products manufacturing | |
| DeRoyal Industries | Knox | Manufacturer of medical & hospital supplies | Operations in TN, AZ, FL, VA and Ireland |
| Dura-Line Corp. | Knox | Manufacturer of high desnity polyethylene pipe, duct, and conduit products | Operations in UK; Spain; Russia; Mexico; India; China; Brazil; Czech Republic; and Malaysia |
| The E. C. Corporation | Knox | Specializing in aerospace and defense research and design | Operations in MA, NV, NJ, NC, PA and VA |
| Eagle Automotive Inc. | Knox | Collision replacement parts wholesaler | 23 branch offices in AL, CO, FL, GA, KY, MI, NE, NC, OH, OK, PA, SC, TN, TX, UT and WA |
| EdAmerica | Knox | Private, non-profit corp providing low-cost student loans nationwide | Operates in 22 states |
| Emerson Process Management | Knox | Vibration anaylizing equipment | operations worldwide |
| Employers Security Company, Inc. | Knox | Detective and armored car services | Operations in Alabama, Florida, Georgia, Kentucky, North Carolina, South Carolina, and Virginia. |
| The H. T. Hackney Company | Knox | wholesale food and equipment distributors | Distribution network covering 21 states |
| Highway Transport Logistics | Knox | Provides bulk transportation and logistics services | Services the United States, Canada and Mexico |
| Holston Gases, Inc. | Knox | Provides industrial and medical gases, welding and cutting supplies | Operations in TN, AL, and KY. |
| House-Hasson Hardware | Knox | America's largest independent regional hardware distributor | Operations in TN & WV |
| Jewelry Television (ACN-TV) | Knox | Satellite-based home-shopping network of precious gemstones, jewelry, and other collectibles | Distributed nationally on cable and satellite TV |
| KaTom | Sevier | wholesale restaurant supplies | global |
| Kelsan, Inc. | Knox | Janitorial supply & services | Operations in TN & NC |
| Kitchen Sales, Inc. | Knox | Kitchen cabinets, countertops & appliances | Locations in East TN |
| MK Technologies Corporation | Knox | Provides engineering solutions, software, training, and complete services | Additional operations in CO and OH |
| Machine Kinetics Corp. | Knox | Industrial machinery | Additional operations in Colorado and Ohio. |
| Massey Electric Co. | Blount | Electrical Contractors | Locations in TN |
| Modern Supply Co. | Knox | Plumbing, hydronic heating, appliance, and kitchen cabinet supplies | operations in TN & VA |
| Navarro Research and Engineering, Inc. | Anderson | Engineering and administrative services firm | Additional operations in 12 ststes |
| Netgain Corp. | Knox | Security services firm sfor companies in national security construction, gov’t services, prisons, manufacturing & education | |
| PAI Corp. | Anderson | Health, safety, environmental & quality assurance | Operations in NV |
| Perceptics LLC | Knox | Computer-integrated systems design | |
| PerfectServe Inc. | Knox | Provides communications platform to hospitals & healthcare systems | offices in Atlanta & Chicago |
| Phillips & Jordan, Inc | Knox | General & specialty contractor | operations in 8 states |
| Phoenix Theatres Entertainment | Knox | Movie Cinema Chain | 25 locations in 15 states |
| Pilot Flying J | Knox | Operates gasoline stations and convenience markets; is the nation's largest retail operator of Travel Centers | Operates in 40 states with over 270 retail interstate properties. |
| Pro2Serve Professional Project Services, Inc. | Anderson | Architectural, engineering and technical services to private and governmental clients worldwide. | Additional offices in 7 states |
| Provectus Pharmaceuticals, Inc. | Knox | Pharmaceutical manufacturing | |
| Purdy Bros. Trucking Co. | Loudon | Trucking firm with service to 48 states & Canada | Terminals in FL, IL, & VA |
| Radio Systems Corp. | Knox | Pet containment systems manufacturing | Operations in VA & China |
| Regal Entertainment Group | Knox | Largest U.S. movie cinema chain | Locations in37 states & DC |
| Rentenbach Engineering Co. | Knox | general contracting, design-build, and construction management services | Offices in TN & NC |
| RIVR Media Enterprices | Knox | Television, film and digital media content and production Concrete construction materials (with additional operations in Tri Cities) |
Offices in TN |
| Ross Pre-Stressed Concrete Co. | Knox | Concrete construction materials | Operations in TN |
| Royal Brass and Hose | Knox | Assembler of brass hose and fittings | Additional operations in KY, IL, GA, AR, FL, & NC. |
| Ruby Tuesday Inc. | Blount | Restaurant chain | Locations in 42 states & 13 nations |
| Sea Ray Boats, Inc | Knox | Fiberglass pleasure boats | Operations in FL |
| Securities Service Network | Knox | Financial Planning Firm | Offices in 18 states |
| Shoffner Kalthoff Mechanical Electrical Svc | Knox | Mechanical & electrical contractor licensed in 12 states | Location in TN |
| SL America Corp. | Anderson | Automotive parts - parking brakes | Facilities in MI & AL |
| Smoky Mountain Materials, Inc | Knox | Building material supplier | Operations in AL, FL & NC |
| Star Construction, Inc | Knox | Water, sewer, & utility lines contractor | locations throughout Eastern U.S. |
| Stokely Hospitality | Sevier | Restaurants; resorts; and local franchises | |
| Stowers Machinery Corp | Knox | Construction & mining machinery equipment rentals | ocations throughout East TN |
| Summitt Medical Group | Knox | Medical billing & Staffing services | |
| Swift Industrial Power, Inc. | Knox | Industrial machinery and equipment | Operations in TN, AL, FL & KY |
| TeamHealth, Inc | Knox | Medical billing & Staffing services | |
| Techmer PM | Anderson | Plastic extrusions/polymer modifiers | operations in 5 states & Brazil |
| Tennessee Valley Authority (TVA) | Knox | TVA operates the dams, locks, and reservoirs of the Tennessee River and its tributaries as one integrated system in order to provide multiple benefits for the region. These benefits include year-round navigation, flood damage reduction, affordable electricity, improved water quality and water supply, recreation, and economic growth. | Operations in TN, AL, GA, KY, MS, NC & VA. |
| The Tombras Group | Knox | Full service advertising agency. | Operations in TN, KY & Washington DC |
| Weigel Stores, Inc | Knox | Convenience stores & service stations | locations throughout East TN |
| WESKEM, LLC | Anderson | Environmental waste management firm | Additional operations in KY |
| Zellweger Uster, Inc. | Knox | Manufacturer of textile testing instruments | Additional operations in NC and Switzerland |
Source: Book of Lists, community websites 2023